Is it beneficial for individuals suffering from ulcerative colitis to consume whey protein?
In the realm of nutrition and inflammatory bowel disease (IBD), a growing body of research suggests that whey protein could potentially offer benefits for those suffering from ulcerative colitis (UC), particularly when derived from donkey milk and processed nonthermally.
A recent study published in 2025, using a mouse model of UC, found that donkey whey protein processed by nonthermal methods alleviated UC symptoms such as weight loss, diarrhea, and colon shortening. It improved mucosal integrity, reduced inflammation by suppressing proinflammatory cytokines, enhanced antioxidant activity, and positively modulated gut microbiota, promoting microbial diversity and balance [1].
While human clinical data specific to whey protein and UC are limited, the beneficial mechanisms identified in animal models—including anti-inflammatory and antioxidant effects—suggest whey protein could be a helpful complementary nutritional strategy for managing UC. Nonthermal processing of whey protein appears critical for preserving these bioactivities [1].
However, it's important to note that UC and IBD involve complex dietary interactions, and individual sensitivity varies. Maintaining adequate nutrition is crucial since UC symptoms may cause weight loss and malnutrition. Meal replacement shakes containing protein (not necessarily whey-specific) are commonly used in IBD care to support nutrient intake during flare-ups, though dietary tolerance needs to be personalized and supervised by healthcare providers [4].
Psyllium husk powder, derived from the seeds of the medicinal plant Plantago ovata, may also offer benefits for people with UC. It helps draw water into the intestines, which can soften stools and ease constipation, a common symptom of IBD. Additionally, a study found that psyllium husk can improve the composition of gut bacteria, particularly in people with constipation [2].
When it comes to protein, people can consume it from a variety of dietary sources such as eggs, fish, poultry, lean meats, lentils, tofu, milk, yogurt, cheese, nuts, seeds, and quinoa. Plant-based proteins, like pea protein, may be a suitable alternative to whey powder for vegans, people who are extremely sensitive to lactose, and people with allergies to other types of protein.
However, certain protein powders may contain added sugars and calories, which may cause weight gain if consumed excessively. It's also worth noting that some protein powders may contain toxins, including heavy metals and pesticides. Choosing a third-party tested product can minimize the risk of contamination.
In conclusion, while current supports mainly come from animal studies, the potential benefits of whey protein for UC patients, particularly donkey whey protein processed nonthermally, are promising. More human clinical research is required to confirm efficacy and safety. People with UC considering whey protein should consult healthcare professionals and dietitians to tailor nutritional approaches to their condition and monitor for tolerance.
- In the realms of health and science, whey protein derived from donkey milk shows potential benefits for those battling ulcerative colitis (UC), contributing to workplace wellness conversations.
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